From Knocked Up to New Year’s Eve, Snakkle Looks Back on Katherine Heigl’s Dazzling Career

katherine heigl that night movie photo 1992

That Night (1992)

Katherine wasn’t alone in making her on-screen debut in this coming-of-age story based on the novel by Alice McDermott. She was joined by Eliza Dushku of Buffy the Vampire Slayer fame.

katherine heigl new canaan high school young yearbook photo 1996

New Canaan High School, Connecticut (1996)

Here’s the fresh-faced smile that caught the attention of glossy magazines and casting agents alike. For more yearbook photos of celebs Before They Were Stars, click here!

katherine heigl under seige 2 movie photo 1995

Under Seige 2 (1995)

Not yet out of high school in real life, Katherine was already going places in Hollywood. Watch her here in a clip from the film where she stars as Steven Seagal’s estranged niece.

katherine heigl as isabel evans roswell photo 1999

Roswell (1999)

As Isabel Evans, an alien-human hybrid, Katherine was on all three seasons of this New Mexico-based sci-fi show.

katherine heigl as izzie stevens Grey's Anatomy photo 2005

Grey’s Anatomy (2005)

Seriously? Yes, seriously, her role as Dr. Isobel “Izzie” Stevens not only catapulted Katherine’s career but won her an Emmy.

katherine heigl seth rogen knocked up movie photo 2007

Knocked Up (2007)

In Judd Apatow’s R-rated blockbuster, Katherine established herself as a leading actress alongside Seth Rogen. Believe it or not, Judd Apatow and Adam Sandler used to be roomies! Find out who else kept house before they made it big!

katherine heigl emmy best supporting actress drama 2007

Frazer Harrison/Getty Images

Emmy Award (2007)

Katherine poses in the pressroom with her Emmy for Outstanding Supporting Actress in a Drama Series for Grey's Anatomy.

katherine heigl ashton kutcher the killers movie photo 2010

Killers (2010)

Katherine stars alongside Hollywood heartthrob Ashton Kutcher. Bet he tweeted about her.

katherine heigl compassion revolution animal charity photo 2010

Jason Merritt/Getty Images

Compassion Revolution Press Conference (2010)

Katherine attended the Jason Debus Heigl Foundation's “Compassion Revolution” press conference in Los Angeles. (The animal advocacy foundation is named for her brother, who died in a car accident at 15.)

Jason Merritt/Getty Images

Katherine and Husband Josh Kelley (2011)

With singer-songwriter husband Josh Kelley, Katherine attends Elle's 18th Annual Women in Hollywood event in October. They probably hurried home to see their nearly three-year-old daughter Nancy Leigh Mi-Eun Kelley (known as Naleigh), whom they adopted from South Korea.