Fran Drescher as Fran Fine in The Nanny

Drescher’s first big break was as an extra on Saturday Night Fever, but it wasn’t until she landed the role of The Nanny’s Fran Fine—a bridal consultant-turned-nanny for a wealthy family in Manhattan—that she became a household name. Funny, sweet, and questionably fashionable, Fran (and her unforgettable nasally voice) not only won the hearts of the Sheffields, but also viewers everywhere.