After playing the self-destructive Alison for so many years, it’s no wonder Thorne-Smith continued her career in sitcoms. We would just want to laugh all day too! After a comedic stint on Ally McBeal, she spent eight memorable years as Jim Belushi’s suburban wife on According to Jim, and she boozed it up once again as Alan’s on-again, off-again love interest on Two and a Half Men. Though Thorne-Smith did not appear on the CW’s Melrose Place reboot, she has stated recently that she would be up for another reunion project of some kind.